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Neuroleptic Drugs and 5HT 1 Receptor:Different Potencies of Various Neuroleptic Drugs on 5HT 1 Receptors in Discrete Regions of the Rat Brain
Author(s) -
Harada Toshiki,
Sato Mitsumoto,
Otsuki Saburo
Publication year - 1985
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1985.tb00810.x
Subject(s) - spiperone , chlorpromazine , receptor , haloperidol , pharmacology , chemistry , 5 ht receptor , 5 ht1 receptor , dopamine receptor , psychology , neuroscience , serotonin , medicine , biochemistry , dopamine
The potencies of various neuroleptic drugs (zotepine, chlorpromazine‐HCl, haloperidol and spiperone) on serotonin, (5HT 1 ) receptors were examined in discrete rat brain regions using the radio receptor assay. The potencies of the neuroleptic drugs on 5HT 1 receptors were clearly differentiated in the discrete brain regions:zotepine was the most potent in the frontal cortex, striatum and brain stem; spiperone was the most potent in the hippocampus. Furthermore, zotepine and chlorpromazine‐HCl produced no great differences among the various regional 5HT 1 receptors, while butyrophenones, haloperidol and spiperone showed remarkable differences. These findings demonstrate that the neuroleptic drugs can be differentiated according to their different affinities for regionally discrete 5HT, receptors in the brain. This suggests that 5HT 1 receptors may be able to be classified into two subtypes:the zotepine and chlorpromazine‐HCl group having a high affinity for one subtype and butyrophenones a high affinity for the other.