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GABA Levels in Cerebrospinal Fluid of Patients with Epilepsy
Author(s) -
Yamamoto Mitsutoshi,
Takahashi Shigeru,
Otsuki Saburo,
Kugoh Toshiaki,
Hosokawa Kiyoshi,
Ogawa Norio
Publication year - 1985
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1985.tb00805.x
Subject(s) - epilepsy , cerebrospinal fluid , medicine , neuroscience , psychology , psychiatry
The lumbar cerebrospinal fluid (CSF) γ‐aminobutyric acid (GABA) levels were measured in 27 patients with epilepsy, another three epileptic patients with status epilepticus and three epileptic patients with chronic cerebellar ataxia. The mean lumbar CSF GABA levels of the 27 patients with epilepsy were not significantly different from those of normal controls. Six of these 27 patients who had daily partial complex and partial motor seizures showed significantly low CSF GABA levels as did the six other patients, three each with status epilepticus and chronic cerebellar ataxia. These findings suggest that some epileptic patients have impaired brain GABAergic neurons.