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Myotonia Induced by Low Chloride Solution: Intracellular Studies by C1 Liquid Ion Exchanger Microelectrode
Author(s) -
Kurihara Teruyuki,
Tanaka Masayuki,
Shioya Keiichi
Publication year - 1984
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1984.tb00798.x
Subject(s) - myotonia , microelectrode , intracellular , chemistry , chloride , myotonia congenita , ion , ion exchange , biophysics , medicine , myotonic dystrophy , biochemistry , electrode , organic chemistry , biology
By exposing the rat hemidiaphragm preparations to various low chloride solutions, it was demonstrated that myotonia can be induced when the extracellular chloride concentration was reduced below 82 mEq/L. Myotonia can be induced simply by reducing the extracellular chloride concentration without any significant reduction of RMP. The intracellular and extracellular chloride activity was measured by the liquid ion exchanger microelectrode. The control intracellular chloride activity was 10.8 mEq/L and that of myotonic specimen in a low chloride solution of 47 mEq/L was 4.4 mEq/L. Chloride conductance was closely related to the extracellular chloride concentration and myotonia was induced when g c1 was 38.3% of the control.