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Muscarinic Cholinergic Receptors of the Convulsive Strain (E1) Mouse
Author(s) -
Mori Koichi,
Fujita Seiichiro,
Kawaguchi Kenji,
Chikami Takashi,
Ohno Kyosuke,
Tsuji Masaki,
Onishi Hiroshi,
Yamagami Sakae,
Kawakita Yukio
Publication year - 1983
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1983.tb00336.x
Subject(s) - muscarinic acetylcholine receptor , hippocampal formation , hippocampus , receptor , acetylcholine , endocrinology , cholinergic , acetylcholine receptor , medicine , strain (injury) , muscarinic acetylcholine receptor m2 , chemistry , muscarinic acetylcholine receptor m4 , muscarinic acetylcholine receptor m3 , scatchard plot , muscarinic acetylcholine receptor m1 , neuroscience , biology
The biochemical characteristics of the muscarinic acetylcholine receptors were studied on the El strain mouse brain by the binding assay using [ 3 H]l‐quinuclydinyl benzylate. Scatchard analyses showed that the receptor density (B max ) of the hippocampus significantly decreased by 26.4% and the affinity (K d ) increased by 18.8% in El(+) compared to dd‐Y. It is suggested that this hippocampal subsensitivity found in El(+) mouse might be strain‐specific, because repeated megimide convulsions failed to produce the same down regulation.