Premium
Effects of Thyrotropin‐Releasing Hormone on Catecholamine Concentration in Various Structures of the Rat Brain
Author(s) -
Niimi Michio,
Takahara Jiro,
Fujino Hisayuki,
Aoki Yoshiyuki
Publication year - 1983
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1983.tb00311.x
Subject(s) - thyrotropin releasing hormone , catecholamine , medicine , endocrinology , dopamine , intravenous bolus , nucleus , bolus (digestion) , chemistry , central nervous system , basal (medicine) , hormone , psychiatry , insulin
Abstract: In an attempt to identify the site of TRH‐action in the central nervous system (CNS), we have measured catecholamine levels in discrete brain regions of rats after an intravenous administration of TRH or a long‐term intraventricular administration of TRH using Alzet's osmotic minipump. An intravenous administration of 50 μg TRH caused a rapid increase in dopamine (DA) concentration in the septal nucleus and then returned to the basal level at 30 min after injection. The concentration of DA in the septal nucleus after the long‐term TRH intraventricular administration was also significantly higher than that in the controls. These results indicate that a long‐term intraventricular administration of TRH as well as a bolus intravenous injection of TRH may affect the release or metabolism of DA in the septal nucleus.