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Regional Inhibition of Monoamine Oxidase Activity by Administration of Clorgyline in Rat Brain
Author(s) -
Kunimoto Norifumi,
Hazama Hidebumi,
Kamase Harutaka,
Mizukawa Rokuro
Publication year - 1983
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1983.tb00308.x
Subject(s) - clorgyline , monoamine oxidase , monoamine oxidase b , dopamine , chemistry , pharmacology , monoamine neurotransmitter , medicine , endocrinology , serotonin , enzyme , biochemistry , receptor
The inhibiting effect of monoamine oxidase (MAO) activities towards 5‐hydroxytryptamine, dopamine and β‐phenylethylamine by an acute and chronic administration of clorgyline was investigated in five locations of the rat brain. Inhibiting the percentage distributed unevenly in each hypothalamic nucleus and in the circumventricular areas, except the median eminence, the percentages were significantly low as compared with the hypothalamic lateral nucleus. A significant percentage of inhibition for type B MAO towards β‐phenylethylamine was noticed in the chronically administered group. In conclusion, the MAO‐inhibiting effect of clorgyline administered intraperitoneally was unevenly distributed in the discrete brain nuclei and the regional difference depended upon the dose and the duration of the clorgyline administration.