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Studies on Amyotrophic Lateral Sclerosis by Neutron Activation Analysis–3. Systematic Analysis of Metals on Guamanian ALS and PD Cases
Author(s) -
Yoshimasu Fumio,
Yasui Masayuki,
Yase Yoshiro,
Uebayashi Yushiro,
Tanaka Shoji,
Iwata Shiro,
Sasajima Kazuhisa,
Gajdusek D. Carleton,
Gibbs Clarence J.,
Chen KwangMing
Publication year - 1982
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1982.tb00268.x
Subject(s) - amyotrophic lateral sclerosis , manganese , calcium , autopsy , chemistry , neutron activation analysis , copper , pathology , medicine , radiochemistry , disease , organic chemistry
Central nervous system tissue autopsy samples from seven Guam amyotrophic lateral sclerosis, four Guam Parkinsonism‐dementia complex and three Chamorro control cases were analyzed for aluminum, calcium, copper and manganese contents using the neutron activation analysis. ALS cases showed a high content of aluminum which corresponded to the area of degeneration in CNS tissue while calcium and manganese each showed a low content. PD cases showed a still higher content of aluminum, diffusely distributed. Copper and manganese levels were high while calcium showed a low content. The low calcium contents may be ascribed to the long period of formalin fixation. These findings support the indication that aluminum may participate in a CNS degenerative process of these diseases with interaction of other metals.