Premium
An Electron Microscopic Study on Atypical Presenile Dementia with Numerous Lewy Bodies in the Cerebral Cortex
Author(s) -
Itoh Tomoko,
Momma Yoshimichi,
Ogasawara Noboru
Publication year - 1982
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1982.tb00260.x
Subject(s) - dementia with lewy bodies , cerebral cortex , neuroscience , pathology , dementia , medicine , psychology , disease
A report was made of an autopsied case of presenile dementia presenting the clinically characteristic symptoms of Alzheimer's disease and Pick's disease. The neuropathological findings were senile changes, namely, numerous senile plaques, neurofibrillary tangles, granulovacuolar degeneration and Pick bodies, etc., and numerous Lewy bodies in the brain stem and in the cerebral cortex. We studied mainly the ultrastructure of Lewy bodies in the cerebral cortex in this paper. The features of ultrastructural components of Lewy bodies presented types which might correspond to the various profiles of Lewy bodies observed by a light microscope. In addition, we studied the senile changes in the cerebral cortex ultrastructurally and considered that some relationship possibly existed between Lewy bodies and senile changes.