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Brain Monoamine Levels and El Mouse Convulsions
Author(s) -
Hiramatsu Midori
Publication year - 1981
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1981.tb00224.x
Subject(s) - serotonin , dopamine , norepinephrine , medicine , endocrinology , monoamine neurotransmitter , epilepsy , ictal , convulsion , biology , neuroscience , receptor
El mice had higher levels of brain dopamine (DA) and serotonin (5‐HT) and a lower level of brain norepinephrine (NE) compared with the other strains of inbred mice. In the interictal stage of “stimulated” El mouse, the brain DA, NE and 5‐HT levels were significantly lower compared with the non‐stimulated El mouse. The administration of 5‐hydroxytryptophan with MK486 markedly depressed the incidence of seizures in the El mouse. Evidence of abnormal DA, NE and 5‐HT metabolism was found at the development age when the seizures became frequent. These results show that 5‐HT may be closely related to the El mouse seizure susceptibility.