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Fine Structure of Experimental Epileptogenic Focus Produced by Intracerebral Implantation of Cobalt‐Gelatine Stick in Rabbits
Author(s) -
Nakamura Ichiro,
Endo Masaomi,
Hosokawa Kunihito,
Isaki Kiminori,
Koyama Yoshiko,
Katsukawa Kazuhiko
Publication year - 1981
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1981.tb00205.x
Subject(s) - lesion , cobalt , ultrastructure , cortex (anatomy) , extracellular , electron microscope , cerebral cortex , focus (optics) , pathology , neuroscience , epilepsy , chemistry , anatomy , biophysics , biology , medicine , microbiology and biotechnology , physics , optics , inorganic chemistry
The experimental epileptogenic focus produced by cobalt‐gelatine stick implantation in the cerebral cortex of rabbits has been studied by electron microscopy. Since our cobalt focus was latent, the bemegride maneuver was intravenously performed to identify the cobalt lesion of the cortex as an epileptogenic focus. The cobalt lesion comprised three different zones. Of the three zones, the reactive zone showed a glio‐mesenchymal scar and prominent ultrastructural changes. The major change of this zone was found in the neurons, neuropils and astrocytes. Electron‐lucent neurons deprived of the usual neuropils surrounding them, widening of extracellular spaces and swollen dendrites in neuropils, and proliferating astrocytes were observed constantly throughout the experimental period. These findings may be significant for the genesis of this type of epilepsy.