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Ethambutol Neuropathy: Clinical and Electroneuromyographic Studies
Author(s) -
Takeuchi Hiroaki,
Takahashi Mitsuo,
Kang Jin,
Ueno Satoshi,
Tarui Seiichiro,
Nakao Yuzo,
Otori Toshihumi
Publication year - 1980
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1980.tb01512.x
Subject(s) - ethambutol , medicine , peripheral neuropathy , optic neuropathy , atrophy , visual field , optic nerve , visual disturbance , surgery , ophthalmology , pathology , tuberculosis , isoniazid , diabetes mellitus , endocrinology
Clinical features including changes in the peripheral nerve conduction were analyzed in 10 cases with ethambutol neuropathy. There were abnormalities in the visual field in seven and optic atrophy in five of 10 cases. Seven of 10 cases complained of numbness in the lower limbs. The age of onset and dose of ethambutol the patients continue to take after the occurrence of visual impairment were found to be important in determining the severity of neurological symptoms. A functional disturbance was more conspicuous in ethambutol neuropathy, particularly in the sensory system than in the motor system so far as the peripheral nerve conduction was serially examined. Some cases still had serious optic disturbances even about seven years after the onset of the disease and the presence of irreversible lesions was suspected.