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Teratogenic Risks of Antiepileptic Drugs in Respect to the Type of Epilepsy
Author(s) -
Seino Masakazu,
Miyakoshi Masako
Publication year - 1979
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1979.tb00773.x
Subject(s) - epilepsy , medicine , primidone , polypharmacy , pregnancy , miscarriage , teratology , incidence (geometry) , pediatrics , congenital malformations , anticonvulsant , gestation , psychiatry , intensive care medicine , biology , physics , optics , genetics
Summary The incidence of malformations and/or miscarriage‐stillbirths was unequivocally higher in offsprings born to mothers with secondary generalized epilepsy or complex partial seizures. Although it was difficult to separate the possible role played by antiepileptic drugs from that of predisposed severity of epilepsy, the teratogenic risks due to medication appeared to be more plausible. Polypharmacy and overdose regimen should be avoided by all means especially during the earlier period of pregnancy.