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An Autopsy Case of Multiple Leucoencephalitis Showing Hemiatrophy of the Brain
Author(s) -
Miyakawa Taihei,
Shikai Lsao,
Suzuki Takaaki,
Toyonaga Keitaro
Publication year - 1979
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1979.tb00176.x
Subject(s) - white matter , atrophy , medicine , pathology , cytoarchitecture , gliosis , neuropathology , autopsy , myelin , anatomy , neuroscience , psychology , central nervous system , magnetic resonance imaging , disease , radiology
Summary A 39‐year‐old female died 25 years after the onset of epileptic seizure. In the clinical course, she suffered epileptic seizures, left hemiparesis and muscular atrophy of the left upper extremity, psychological character change, dementia, forced laughter and hallucinatory and delusional states. Pathologically, severe changes were found in the right hemisphere consisting of lesions of white matter with myelin loss, especially in the frontal, temporal and occipital lobes. Gliosis was diffusely observed in the white matter excepting areas with severe changes. In some parts of the cortex, the cytoarchitecture was destroyed and in this area, blood vessels numerously increased. In the left occipital white matter, perivascular infiltration mainly consisting of lymphocytes was observed with numerous fat granule cells and gemystocytic astrocytes around them. The present case may belong to the category of multiple leucoencephalitis, however, it had many characteristic features, such as a long clinical course (25 years) and pathologically revealed hemiatrophy of the brain.