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Diagnostic and Prognostic Significance of Electroencephalography with Intravenous Diazepam in Epilepsy
Author(s) -
Kurokawa Toru,
Yokota Kiyoshi,
Mitsudome Akihisa,
Shibata Rumiko,
Takashima Sachio,
Goya Nagahide
Publication year - 1979
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1979.tb00169.x
Subject(s) - diazepam , electroencephalography , anesthesia , epilepsy , medicine , seizure disorders , psychiatry
Summary Thirty cases of intractable epilepsy in children were investigated to observe the correlation between the suppression of seizure discharges to intravenous diazepam and the type of seizure or effects of subsequent therapy. Suppression of seizure discharges were bilaterally poor in 75% of the cases with infantile spasms and 89% of cases with Lennox syndrome and other generalized seizures while it was unilaterally poor in 80% of the cases with focal or unilateral seizures. ACTH or steroid therapy was clinically and electroencephalographically effective in 80% of the cases with good suppression responses and in none of cases with good suppression that was resistant to the therapy. On the other hand, clinical seizures were not controlled in 73% of the cases showing poor suppression and EEG did not reveal improvement in 82% of the cases with poor suppression. EEG with intravenous diazepam is valuable for understanding the pharmacophy‐siological mechanism of epilepsy and it may be possible to select cases as candidates for ACTH or steroid therapy using this technique.