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A Morphologic Study of Central Nervous System Aging in Hiroshima, Japan
Author(s) -
Wollmann Robert L.,
Mitsuyama Yoshio,
Webber Larry S.
Publication year - 1978
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1978.tb00148.x
Subject(s) - senile plaques , hippocampus , pathology , arteriosclerosis , degeneration (medical) , central nervous system , medicine , alzheimer's disease , disease
Summary The presence of intraparenchymal small vessel arteriosclerosis, senile plaques, neurofibrillary tangles and granulovacuolar degeneration was quantified in the brains of autopsied patients from three age groups: 1) 90–99 years old 2) 70–79 years old and 3) 50–59 years old. Neurofibrillary tangles particularly in the hippocampus were the best indicator of chronologic aging, but senile plaques and granulovacuolar degeneration were also age related. Intraparenchymal small vessel sclerosis, cerebral infarctioii and hemorrhage, cause of death and radiation exposure at the time of the atomic bomb explosion in Hiroshima apparently had little or no effect on the development of these aging changes. Each type of aging change appeared to be indepandent of the others, to progress at different rates and perhaps to be a response to a different combination of physiologic processes.