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Induction of the Six C/Sec Spike and Wave by Diphenhydramine Hydrochloride in Healthy Male Adults
Author(s) -
Hosokawa Kiyoshi,
Hirata Junichiro,
Kugoh Toshiaki,
Otsuki Saburo
Publication year - 1978
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1978.tb00144.x
Subject(s) - diphenhydramine hydrochloride , diphenhydramine , dose , anesthesia , medicine , hydrochloride , chemistry , histamine , organic chemistry
Summary Diphenhydramine hydrochloride (DPHm) solution 1.5% was given intravenously to 375 healthy males (mean age; 23.8 years) at a rate of 30mg/min. The dosages injected were 2mg/kg (N = 157); 1.5mg/kg (N = 94); 1.0mg/kg (N=72); 0.5 mg/kg (N = 52). As a result, the 6c/sec spike and wave discharges (WSP) was found in 19.7%, 9.6%, 20.8%, and 15.4% of cases, respectively. Comparisons were made between the WSP incidence versus past histories and Cornell Medical Index results, and between WSP positive and WSP negative subjects. No significnat differences were observed in any of these parameters.