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Mechanism of Histopathological Changes of Nerve Cells Experimentally Induced by Chronic Alcohol Poisoning
Author(s) -
Miyakawa Taihei,
Sumiyoshi Shiro,
Deshimaru Motonori,
Hattori Eisei,
Shikai Isao
Publication year - 1977
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1977.tb02727.x
Subject(s) - nerve cells , atrophy , cerebellum , ethanol , alcohol , chronic alcoholism , granule (geology) , pathology , chronic alcoholic , chemistry , histopathological examination , medicine , endocrinology , biology , microbiology and biotechnology , biochemistry , paleontology
SUMMARY Experimental alcoholism was produced in rats by supplying them with 15% ethanol as the only source of liquid for a whole year. Histopathological examination revealed that Purkinje cells and granule cells in the cerebellum mainly showed such changes as decrease of ER, ribosomes and severe atrophy of the nerve cells. It might be speculated that these changes were caused by the disturbance of protein synthesis in the nerve cells induced by chronic alcohol effect.