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Corticocerebellothalamic Degeneration with Chromatolytic Neuronal Swelling: A Light and Electron Microscopic Case Study
Author(s) -
Kaiya Hisanobu,
Yoshimura Tsuyoshi,
Namba Masuyuki
Publication year - 1977
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1977.tb02725.x
Subject(s) - neurofilament , cerebellar cortex , neuroscience , thalamus , endoplasmic reticulum , anatomy , gliosis , cerebral cortex , axon , cortex (anatomy) , cerebellum , chemistry , biology , pathology , medicine , biochemistry , immunohistochemistry
SUMMARY A 50–year‐old woman showing psycho‐organic syndrome, cerebellar symptoms, choreatic involuntary movements, Romberg's sign and epileptic fits over a period of 14 years, was neuropathologically studied. The calcarine and postcentral cortex, the medio‐dorsal nucleus of the thalamus and the cerebellar cortex were affected with neuronal loss and astrocytic gliosis. Neurons in various regions showed chromatolytic neuronal swelling. Ultrastructurally, these chromatolytic neurons contained a large hollow core with numerous mitochondria, dispersed rough endoplasmic reticulum, degenerated cisternal structures and a few neurofilaments. Some neuronal mitochondria showed membranous trans‐somal bridges composed of about 60 Å parallel filaments with a spacing of about 80 Å.