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Verteilungsmuster der senilen Veränderungen in den Hirnstammkernen
Author(s) -
Yamada Michio,
Mehraein Parviz
Publication year - 1977
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1977.tb02722.x
Subject(s) - substantia innominata , senile plaques , nucleus basalis , pathology , cortex (anatomy) , nucleus , glial fibrillary acidic protein , alzheimer's disease , anatomy , biology , neuroscience , medicine , central nervous system , cholinergic neuron , disease , immunohistochemistry
SUMMARY A quantitative study of senile plaques and Alzheimer's fibrillary changes in nuclei of the brain stem and hypothalamic regions in senile dementia and Alzheimer's disease demonstrated these particular changes to be far less marked than those observed in the cortex. In seven cases each of senile dementia and Alzheimer's disease, the numbers of senile plaques and undergoing Alzheimer's fibrillary changes were determined and compared between the cortex and 17 nuclei in the brain stem and hypothalamic regions. In all cases, four cortical regions were noted to have undergone severe changes, while some of nuclei of the brain stem showed Alzheimer's fibrillary changes. Senile plaques were very few in the brain stem; the substantia innominata, nucleus centralis raphe and corpus mammillare were found to exhibit a slight degree of this pathological change in five cases only. Even in those nuclei of the brain stem which were relatively abundant in Alzheimer's fibrillary changes, the number of areas undergoing such changes was no more than one‐tenth of that of the cortex. Most abundant in Alzheimer's fibrillary changes were the nucleus centralis superior and nucleus dorsalis raphe, followed by the nucleus rnagnocellularis, formatio reticularis, nucleus caeruleus and nucleus alae cinereae. These changes, though of a slightest degree, were also observed in the substantia innominata, substantia griesea cntralis mesence‐phali and nucleus originis nervi cochlearis ventralis. Worthy of a paticular note is that nuclei which were most severely affected with these senile changes are those having mono‐amines.