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Function of Hypothalamo‐Pituitary Thyroid Axis in Depressed Patients
Author(s) -
Yamaguchi Takahisa,
Hatotani Noboru,
Nomura Junichi,
Ushijima Yuri
Publication year - 1977
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1977.tb02718.x
Subject(s) - hypothalamic–pituitary–thyroid axis , medicine , basal (medicine) , endocrinology , depression (economics) , pathogenesis , trh stimulation test , thyroid function , thyroid , thyrotropin releasing hormone , psychology , thyroid hormones , hormone , insulin , economics , macroeconomics
SUMMARY Nineteen out of 51 depressed patients showed abnormal TSH response to TRH in terms of exaggerated, diminished and delayed responses. The basal value of T 3 and its response to TRH were significantly lower in patients with delayed or diminished response than in the normal subjects. These results indicate that the dysfunction of the hypothalamo‐pituitary thyroid axis plays an important role in the pathogenesis of depression.