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Effects of Manganese, Calcium, Magnesium and Lithium on the Ouabain‐Induced Seizure
Author(s) -
Inoue Naohide,
Tsukada Yasuo,
Barbeau André
Publication year - 1977
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1977.tb00135.x
Subject(s) - ouabain , magnesium , calcium , lithium (medication) , manganese , chemistry , medicine , pharmacology , endocrinology , sodium , organic chemistry
Summary The effects of the intra ventricularly administered cations (Mn 2+ , Ca 2+ , Mg 2 + and Li+) against the seizure induced by ouabain (3 μg) were investigated. Mn 2+ , Ca 2+ and Mg 2+ caused definite sedation and decreased locomotor activity. But Li + was without significant behavioral effect at the doses applied. Among the cations used, Mn 2+ , Ca 2+ and Mg 2+ showed significant anticonvulsive effect on the ouabain‐induced seizure. In comparison, on the dose and molarto‐molar basis, the potency of anticonvulsive action was in the following order: Mn 2+ > Ca 2+ > Mg 2+ . On the contrary, the higher dose of Li + potentiated the ouabaininduced seizure. The importance of the increased Ca 2+ level in the extracellular space or the inhibition of Ca 2+ uptake as the anticonvulsive effect of Ca 2+ , Mn 2+ and Mg 2+ was discussed.