Premium
A Study on Psychomotor Epilepsy with “Kindled” Cat Preparations
Author(s) -
Sato Mitsumoto
Publication year - 1976
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1976.tb02279.x
Subject(s) - epileptogenesis , hippocampal formation , epilepsy , hippocampus , cats , reserpine , ictal , neuroscience , psychology , kindling , catecholamine , anesthesia , medicine
SUMMARY Seizure development was examined in amygdaloid (AM), hippocampal (HIPP) and septal (SEPT) “kindled” cats by behavioral and electrographic methods. HIPP seizure developed into motor seizure after establishing secondary epileptogenesis in AM and globus paliidus. A secondary epileptogenesis in the hippocampus was not necessary for AM seizures to develop into generalized convulsions. The SEPT seizure development was almost identical to the hippocampal seizure development. This latter finding suggests that psychomotor epilepsy may not only be triggered by the HIPP and AM focus but by the septum and its related structures. In the second experiment, the effect of various neuroactive agents on the interictal discharge frequency was studied in AM and HIPP kindled cats. Clear antagonistic action of L‐Dopa against reserpine or α‐MPT induced increase of IID frequency was observed. Viewed in conjunction with our previous assay study of catecholamine that showed a marked depletion of both norepi‐nephrine and dopamine, in hippocampal kindled cat brain, it can be concluded that catecholamine inhibits the establishment and activation of the kindled epileptic neuro‐circuits.