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Lennox‐Gastaut's Syndrome—Prognosis of the Secondary Generalized Epilepsies
Author(s) -
Komai Sumiya
Publication year - 1976
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1976.tb02265.x
Subject(s) - lennox–gastaut syndrome , ictal , pediatrics , electroencephalography , spike and wave , epilepsy , psychology , age of onset , medicine , audiology , neuroscience , disease
SUMMARY On 62 cases with Lennox‐Gastaut's syndrome aged four to 31, the clinical‐electro‐encephalographic findings were summarized as follows;1 (1) Age of onset was over 10 years in 10 cases (16.1%). 2 Mental deficiencies were more severe in those with onset earlier than age three. 3 Behavioral problems were observed in 34 cases (54.8%); 21 with hyperactive and 13 with hypoactive ones ‐ 18 hyperactive cases (85.7%) with the onset taking place before age six, and 12 hypoactive cases (92.3%), all whose age is now over 10. 4 The number of clinical seizures showed a tendency in which monoictal manifestation decreased from 25 to three whereas polyictal one increased from 13 to 59 cases during the course of a decade. 5 Interictal EEG findings were pseudo‐rhythm of slow spike‐wave with or without focal spikes, and so‐called runs of rapid spikes during sleep recording. Focal spikes were observed in 25 cases (40.3%); mainly in the frontal area among those under 10 years old, and in the anterior temporal area among those over 20. The rapid spikes were demonstrated in 19 cases (30.6%) in the over‐15 age group and appeared to be correlated with epileptic drop seizures and atypical complex absences.