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Regional Distribution of Choline Acetyltransferase and Acetylcholinesterase Activity in Baboon Brain
Author(s) -
Nakamura Yutaka,
Hassler Rolf,
Kataoka Kiyoshi,
Bak I. J.,
Kim J. S.
Publication year - 1976
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1976.tb00121.x
Subject(s) - caudate nucleus , baboon , choline acetyltransferase , nucleus basalis , acetylcholinesterase , chemistry , putamen , nucleus , basal ganglia , cerebral cortex , hippocampus , neuroscience , aché , substantia nigra , central nervous system , endocrinology , enzyme , biochemistry , biology , dopamine , cholinergic neuron , dopaminergic
Summary (1) The activities of choline acetyltrans‐ferase (ChAc) (EC 2.3.1.6) and acetyl‐cholinesterase (AChE) (EC 3.1.1.7) were determined in about one hundred regions and subregions of baboon brain. The activities and distributions of these enzymes were in comparable to those found previously in the brains of other species. (2) ChAc activity was highest in the in‐terpeduncular nucleus, where it was about twice that in the putamen, the region previously thought to be the richest in this enzyme. The caudate nucleus, the substantia perforata, the nucleus basalis, the central part of the amygdala and the oculomotor nucleus also had high activities. The activities in the cerebral and cerebellar cortex were less than one twentieth of that in the inter‐peduncular nucleus. (3) The distribution of AChE activity was not entirely in parallel with that of ChAc.