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Immunoglobulin Abnormalities in Epileptic Patients Treated with Diphenylhydantoin
Author(s) -
Yabuki Seiso,
Nakaya Koji
Publication year - 1976
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1976.tb00115.x
Subject(s) - medicine , epilepsy , phenytoin , antibody , lymphatic system , immunology , psychiatry
Summary An immunologic study was made on 170 epileptic patients treated with antiepileptic drugs. The most noteworthy finding was that the serum IgA was decreased in 22 patients, and an IgA deficiency noticed in 12 of them. The blastic transformation rate of lymphocytes in PHA‐containing cultures appeared low in seven out of 12 patients. Other findings included decreased serum IgM and IgG in some patients. These abnormalities were not encountered in epileptic patients taking no anti‐epileptic drugs. Therefore, they could be considered as the side effects of antiepileptic drugs. In all patients manifesting these abnormalities, diphenylhydantoin was used in common. It was surmised that the above‐mentioned immunologic abnormalities caused by anti‐epileptic drugs, especially diphenylhydantoin, had resulted from disorders of the antibody producing organs in the bone mar‐row‐thymus‐lymphatic system.