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Development of Kindled Amygdaloid Seizures After Section of the Forebrain Commissures in Rats
Author(s) -
McCaughran James A.,
Corcoran Michael E.,
Wada Juhn A.
Publication year - 1976
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1976.tb00112.x
Subject(s) - kindling , forebrain , commissure , corpus callosum , anterior commissure , amygdala , neuroscience , psychology , hippocampal formation , epilepsy , stimulation , hippocampus , central nervous system
Summary Repeated application of electrical stimulation to amygdala results in the progressive development and elaboration of clinical and electrographic seizures (kindling). The rate of kindling was compared in control rats and rats with various amounts of damage to the forebrain commissures. Partial or total tran‐section of corpus callosum, hippocampal commissure, and anterior commissure did not retard the rate of kindled seizure development. In the few cases in which a retarded rate of kindling was observed, there was always evidence of unintended damage to rostral thalamic nuclei; no such damage was seen in forebrain‐bisected rats that kindled at control rates. These results indicate that the forebrain commissures do not play an essential role in amygdaloid kindling, and they suggest that nuclei in the rostral thala‐mus may participate in this phenomenon.