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Effects of Various Cerebral Metabolic Activators on Glucose Metabolism of Brain
Author(s) -
Watanabe Shosuke,
Kono Sawayo,
Nakashima Yoshihiko,
Mitsunobu Katsusuke,
Otsuki Saburo
Publication year - 1975
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1975.tb02324.x
Subject(s) - metabolism , cerebral blood flow , carbohydrate metabolism , citicoline , endocrinology , metabolite , medicine , chemistry , perfusion , metabolic pathway , cytidine , biology , biochemistry , enzyme
The effects of various metabolic activators on the glucose metabolism of the perfused cat brain have been investigated. (1) When the perfusion is done with the blood containing cytidine monophosphate, the glucose metabolism of the brain is enhanced, as compared to the perfusion with the blood without cytidine monophosphate. There is no marked change in the cerebral metabolic rate and in the contents of intermediate metabolite of glucose in the brain. (2) Citicoline enhances the incorporation of blood glucose into the brain and its metabolism in the brain. It increases slightly the cerebral blood flow rate and decreases the accumulation of lactate in the brain. (3) Either Pyrithioxin or Meclophenoxate has no effect on the glucose metabolism of the brain nor on the cerebral metabolic rate.