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Synaptic Alterations in the Hypothalamus of the Rabbit Following Long‐Term Chlorpromazine Administration
Author(s) -
Koizumi Junzo,
Shiraishi Hiroyasu
Publication year - 1973
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1973.tb02658.x
Subject(s) - chlorpromazine , postsynaptic potential , hypothalamus , endocrinology , medicine , neuroscience , chemistry , biology , receptor
SUMMARY Following long‐term administration of chlorpromazine, the brains of rabbits were examined by electron microscopy, with special reference to the synaptic alterations in the hypothalamus, and compared with the normal materials. After two months' intramuscular injections of chlorpromazine (15 mg/kg/day), fine granular or fibrillar materials appear in the postsynaptic regions of some dendrites in the tuber cinereum of the hypothalamus. And the postsynaptic regions of some dendrites are extremely shrunken and embraced by astroglia. The animals showed neuroleptic and extrapyramidal symptoms throughout the period. These synaptic findings are interpreted as degenerative alterations induced by the long‐term administration of chlorpromazine.