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Synaptic Alterations in the Rabbit Hypothalamus Following Long Term Administration of Haloperidol
Author(s) -
KOIZUMI Junzo,
SHIRAISHI Hiroyasu
Publication year - 1972
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1972.tb01136.x
Subject(s) - haloperidol , butyrophenone , hypothalamus , synaptic vesicle , endocrinology , chemistry , axon , medicine , pharmacology , neuroscience , biology , vesicle , dopamine , biochemistry , membrane
Summary The tuberal regions of the hypothalamus of rabbits were examined under the electron microscope following long term administration of haloperidol (a psychotropic drug of the butyrophenone group) with special consideration of synaptic changes in their hypothalamus and were compared with normal materials. After three to five months' intramuscular injections of haloperidol (2 mg/kg/day), in the regions were observed various types of synaptic changes; namely densely accumulated synaptic vesicles in some boutons, a few synaptic vesicles in the clear matrix of some boutons, tubular profiles in some axon terminals and mitochondrial accumulation in some boutons. Those animals showed neuroleptic symptomes and extrapyramidal ones throughout the period. These various types of synaptic alterations are interpreted as the early degenerative changes induced by the long term administration of haloperidol.