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Central Nervous Actions and Screening Methods of Antidepressants
Author(s) -
OGURA Chikara,
KIMISHIMA Kenjiro
Publication year - 1972
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1972.tb01135.x
Subject(s) - nialamide , physostigmine , hexobarbital , imipramine , diazepam , inhibitory postsynaptic potential , amitriptyline , pharmacology , acetylcholine , methamphetamine , neuroscience , anticonvulsant , amobarbital , chemistry , anesthesia , psychology , medicine , epilepsy , biochemistry , alternative medicine , pathology , enzyme , microsome
Summary Mechanism of central actions of antidepressants were studied in experimental animals. Tests were made on general behavior, anticonvulsant activity in maximal electroshock seizure, antireserpinic action, antagonistic action to methamphetamine‐excitation, anesthesia induced by hexobarbital, hypertension due to noradrenalin, hypotension induced by acetylcholine, anti‐tremorine action and antagonism for physostigmine in unanesthetized mice and rabbits. In these tests, it seemed that the mechanism of antidepressants is related to the changes of biogenic amines in the brain and to the central autonomic functions. Namely, imipramine, amitriptyline and nialamide were related intimately to the changes of biogenic amine and to the inhibitory effects of parasympathetic functions. Diazepam was connected with the tranquilizing effects and the inhibitory effects of parasympathetic functions, and dimethylaminoethanol had no relation to the autonomic functions.