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Fine Structural Changes of the Rabbit Brain in the Cardiazol‐Convulsion
Author(s) -
KOIZUMI Junzo,
SHIRAISHI Hiroyasu
Publication year - 1972
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1972.tb01121.x
Subject(s) - globus pallidus , hippocampus , neuroscience , hippocampal formation , cerebral cortex , cytoplasm , putamen , caudate nucleus , cerebellar cortex , hypothalamus , electron microscope , status epilepticus , chemistry , cortex (anatomy) , convulsion , thalamus , biology , central nervous system , basal ganglia , epilepsy , biochemistry , physics , optics
Summary The cerebral cortex, cerebellar cortex, hypothalamus, caudate nucleus, putamen, globus pallidus and hippocampus of the rabbit during the status epilepticus induced by the cardiazol injection were examined under the electron microscope, and were compared with the normal materials. Various fine structural alterations are observed in the neurons of the examined regions, especially in those of the hippocampal and hypothalamic regions. In the nerve cell cytoplasm of these regions, ribosomes are diffusely scattered all over the cytoplasmic matrix losing their original arrangement. The synaptic vesicles have a tendency to be distributed unevenly or to be lumped together in the synaptic boutons there. Glycogen granules in both the neurons and the glial cells of all the examined regions disappear completely. These findings might bs due to an energy exhaustion in the brain metabolism by the convulsive activity.