Premium
Quantitative Pharmaco‐Electroencephalography in Early Evaluation of Psychotropic Drugs*
Author(s) -
ITIL Turan M.,
ULETT George A.,
FUKUDA Tetsuo
Publication year - 1971
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1971.tb01503.x
Subject(s) - electroencephalography , drug trial , scalp , clinical trial , drug , psychotropic drug , medicine , computer science , pharmacology , pathology , psychiatry , surgery
Summary Our studies have shown that the method of quantitative pharmaco‐electroencephalo‐graphy, using digital computer period analysis of the EEG and statistical procedures in the evaluation of a new drug can: a) determine the drug's central effectiveness when given the first time in man, b) predict its clinical value, and c) predict its effective single dosage ranges. Although the scalp‐recorded EEG is a less than perfect method of evaluating human behavior, our experimental studies, as well as clinical trials, have demonstrated that it is an extremely useful approach in the very early evaluation of new drugs.