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Changes in Blood Ammonia Levels Induced by Electro‐Stimulation of the Hypothalamus in Rabbits
Author(s) -
HIGASHIMURA Teruhiko,
MATSUDA Yoshihiro,
KAMIYA Shigenori
Publication year - 1970
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1970.tb01458.x
Subject(s) - stimulation , hypothalamus , ventromedial nucleus of the hypothalamus , endocrinology , thalamus , medicine , period (music) , ammonia , nucleus , chemistry , lateral hypothalamus , biology , neuroscience , biochemistry , physics , acoustics
Summary Changes in blood ammonia levels induced by intracerebral electrical stimulation were studied in rabbits with permanently implanted electrodes in the hypothalamus and the thalamus. Stimulation of the ventromedial nucleus of the hypothalamus for a period of two hours resulted in blood ammonia levels 1.5 to 2 times as high as those of the non‐stimulated controls, but after a 6‐hour stimulation period these levels returned to equal those of the controls, and after a 12‐hour stimulation period of the same nucleus they tended to become less. Stimulation of the lateral hypothalamic area or the centre médian nucleus of thalamus elicited no significant change in blood ammonia levels. The possibility that ammonia metabolism in the liver may be modified through some functional linkage between the brain and the liver was suggested.