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A COMBINED TECHNIQUE OF HISTOCHEMISTRY, MICRO‐DISSECTION AND THIN‐LAYER CHROMATOGRAPHY APPLICABLE TO LIPID STORAGE DISEASES
Author(s) -
Austin James H.,
Yokoi Susum
Publication year - 1967
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1967.tb00073.x
Subject(s) - metachromatic leukodystrophy , thin layer chromatography , cerebral cortex , chemistry , economic shortage , pathology , chromatography , medicine , neuroscience , biology , linguistics , philosophy , government (linguistics)
S ummary A procedure is noted in which histochemical and microdissection techniques arc combined with thin‐layer chromatography. Representative results are illustrated for distended ganglion cells in a controlled study of human cerebral cortex. Diseases chosen as examples are Tay‐Sachs' disease, gargoylism and metachromatic leukodystrophy. Factors are discussed which aid or interfere with the application of this kind of approach to the study of cerebral cortex in some lipid deposition diseases.