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SUCCESSIVE MEASUREMENTS OF URINARY 5‐HIAA IN MENTAL ILLNESS WITH SPECIAL REFERENCE TO DIURNAL CHANGES AND LOADING TEST WITH TETRABENAZINE
Author(s) -
Hirose Masashi
Publication year - 1966
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1966.tb01223.x
Subject(s) - tetrabenazine , urine , schizophrenia (object oriented programming) , anesthesia , psychomotor agitation , medicine , psychology , psychiatry , dopamine
S ummary1) Successive measurement of 5‐HIAA excretion in relation to changes in the clinical condition revealed a tendency to a relative increase during the state of impaired consciousness, emotional disturbance or psychomotor restlessness. 2) Diurnal variations of 5‐HIAA levels in 3 hour urine fractions were the greatest in acute psychotics followed by organic psychotics, chronic schizophrenics and controls. Acute psychotics tended to stabilize with clinical improvement, but still were relatively unstable even in states of near remission. In the chronic schizophrenic group, variation was relatively small, about the same as in the control group. 3) No significant difference was demonstrated between the chronic schizophrenic and control groups in terms of the increase response of the 5‐HIAA level after L‐tryptophan loading. 4) Loading of tetrabenazine resulted in maximum release of 5‐HIAA within 9 hours and recovery to the initial level in 18 hours in the control group, while abnormal responses were seen in the three groups of psychotics, as follows;a) In the chronic schizophrenic group, the maximum level of 5‐HIAA was reached more slowly and the recovery time prolonged (“delayed and probnged response”). b) In the acute psychotic group, 5‐HIAA level was very high and recovered very rapidly (“excessive response”). c) In the organic psychotic group, increase of 5‐HIAA level was more or less similar to that of the contro? group, but recovery tended to be delayed (“prolonged response”).