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“EXPERIMENTAL STUDIES ON CEREBRO‐HEPATIC RELATIONSHIP — EFFECTS OF SEVERAL CONDITIONS ON ENZYME ACTIVITIES IN RAT LIVER AND BRAIN, AND ON ESTROGEN INACTIVATION IN RAT LIVER —”
Author(s) -
Nomura Junichi,
Maeda Masanori,
Nakazawa Kinya,
Hatotani Noboru
Publication year - 1965
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1965.tb00042.x
Subject(s) - endocrinology , medicine , arginase , hypophysectomy , estrogen , enzyme , enzyme assay , chemistry , adrenalectomy , carbon tetrachloride , reductase , hormone , biology , biochemistry , amino acid , organic chemistry , arginine
S ummary 1. Due to liver injury induced by carbon tetrachloride, the activities of GPT, GOT, arginase, tryptophan pyrrolase and δ 4 ‐ ‐ 3‐ketosteroid reductase in rat liver and the ability of rat liver to inactivate estrogen decreased, while the activities of GPT and GOT in the brain were inversely increased. Decrease in the activities of GPT, GOT and arginase in the liver and the ability of the liver to inactivate estrogen were also to be brought on by forced running or immobilization. 2. LSD increased the activity of hexokinase in the brain, but it had no effect on the enzyme activities of the liver or on estrogen inactivation by the liver. 3. Stress conditions such as forced running, immobilization, exposure to cold, and the administration of chlorpromazine significantly increased the activity of tryptophan pyrrolase in rat liver. Removal of the adrenals did not affect the increase of enzyme activity, but ‘hypophysectomy’ completely abolished the enzyme induction.