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EFFECT OF CERTAIN SUBSTANCES ISOLATED FROM ‘MATATABI’ ON THE EEG OF CAT
Author(s) -
Yoshii N.,
Hano K.,
Suzuki Y.
Publication year - 1963
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1963.tb00003.x
Subject(s) - thalamus , reticular formation , hippocampus , cortex (anatomy) , caudate nucleus , reticular connective tissue , chemistry , midbrain reticular formation , electroencephalography , hypothalamus , reticular activating system , cats , cerebral cortex , neocortex , neuroscience , medicine , endocrinology , stimulation , anatomy , psychology
Summary The authors examined the effects of three components of ‘Matatabi’ extract, beta‐phenylethylalcohol, actinidine and ‘Matatabi’‐lactone isolated by Sakan, Fujino, Murai et al. on cats, dogs, rabbits and rats. 1) The minimal effective dosss in the intravenous injection were on Beta‐phenylethylalcohol: 10 ‐ ‐ 3 , actinidine: 10 ‐ ‐ 6 , and ‘Matatabi’‐lactone: 10 ‐ ‐ 4 , for each. 2) The beta‐phenylethylalcohol and actinidine have salivary effects similar to that of pilocarpine, when they were given per os. (‘Matatabi’‐lactone was not tested on salivary effect.) 3) The three ‘Matatabi’ components had no effect on respiration but slightly lowered the blood pressure through the vagal nerves. The blood pressure effect was abolished by vagotomy and atropine. 4) These three substances had similar effects on the EEGs regardless of the route of administration: intravenous injection, micro‐injection into the subcortical structures and cortical application, though minimal effective doses were different from each other. The data suggest that they influence first the electrical activities of the limbic system (hippocampus, amygdaloid) and thgn the hypothalamus, reticular formation, specific and non‐specific nuclei of the thalamus, caudate nucleus, and last the cortex to induce single spikes. Sometimes seizure discharges were produced in the hippocampus, hypothalamus, reticular formation and in other structures independently or synchronously. 5) By large doses basic waves disappeared from the cortex and subcortex (flat EEG), and were replaced by synchronous spikes with intrinsic frequency. 6) In the early stage spindles appeared in the cortex and subcortex (specific and non‐specific nuclei of the thalamus, hippocampus and reticular formation). When sharp waves appeared in the cortex and subcortical structures, spindle bursts of spikes readily followed them (evoked spindles). 7) The 3 or 6 per second waves burst, 4–6 and/or 9–14 per second positive spikes and hypsarhythmia were sometimes seen in the cortex. 8) Atropine abolished all these abnormal EEG's. Nembuthal depressed the EEG flat but didn't affect the spikes or sharp waves produced by the ‘Matatabi’ components. 9) It is suggested that the ‘Matatabi’ components act on the cholinergic neurons in the brain, especially in the limbic system, hypothalamus, reticular formation and thalamic nuclei, that those neurons in the pontine and medullar reticular formation, when stimulated, make the EEG flat to readily induce the intrinsic rhythms, and those in the cortex and thalamus build up waves 6 per second waves burst, 6 and/or 14 positive spikes, and those, when irregularly stimulated, are ready to produce hypsarhythmia. 10) Cholinergic neuron system in the brain are suggested by the figures 12 and 13 got by the micro‐injection and cortical application of these ‘Matatabi’ components.