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THE EFFECT OF HIPPOCAMPAL LESlON UPON CONDITIONED AVOIDANCE BEHAVIOR IN CATS
Author(s) -
Yasukochi G.,
Haruta Y.,
Tsutsumi S.
Publication year - 1962
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1962.tb01214.x
Subject(s) - cats , hippocampal formation , lesion , hippocampus , psychology , neuroscience , avoidance response , abnormality , anesthesia , medicine , audiology , psychiatry
Summary To study the role of hippocampus in memory function, the effects of its lesion upon conditioned behavior were investigated. Eighteen adult cats were divided into two groups; the first group (6 cats) were given electrolytical lesion of hippocampus bilaterally after the training of conditioned avoidance, while one half (6 cats) of the second group (12 cats) were delivered also bilateral and another half unilateral (3 cats each, left and right) hippocampal damage before training. Results were as follows: 1) Bilateral hippocampal lesion delivered to preoperatively trained cat resulted no remarkable impairment in its avoidance behavior. 2) Bilateral hippocampal lesion delivered before training showed markedly impaired ability to acquire the avoidance behavior in cats. 3) Unilateral hippocampal lesion, regardless whether it was the left or the right side, did not bring any alterations in acquisition of avoidance behavior. Authors concluded, therefore, that the hippocampus played an essential role in acquisition of conditioned avoidance behavior, but had little significance in retention of it. We are obliged to offer hearty thanks to our director, Prof. Sakurai for his kind guidance.