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STUDIES ON PROTEIN‐BOUND POLYSACCHARIDE HEXOSE (PBP) OF THE CEREBROSPINAL FLUID IN NEUROPSYCHIATRIC FIELDS: Method for Quantitative Measurement and Survey in Normal Subjects and Schizophrenic Patients
Author(s) -
Sakurada Sho,
Tanaka Zenryu,
Sakurada Takashi
Publication year - 1960
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1960.tb02228.x
Subject(s) - cerebrospinal fluid , gastroenterology , medicine , schizophrenia (object oriented programming) , normal values , surgery , psychiatry
Summary By modified method of the Roboz et al's measurement of CSF‐PBP, there were measured the values of CSF‐PBP in 19 cases of peychopathics regarded as standing under sound mental states as well as in neurotics in remission and in 29 cases of schizophrenics, leading to the following results.1 The values of CSF‐PBP of 19 cases regarded as normal gave a distribution range from 4 mg/L to 8 mg/L, with an average of 6.5 ± 1.0 mg/L. This was regarded here as the normal limit values of CSF‐PBP. 2 The values of CSF‐PBP in 29 cases of schizophrenics were within the range from 2mg/L to 12mg/L, with mean value of 6.3±3.1 mg/L. 19 out of 29 cases (65.6%) showed normal values, 5 cases (17.2%) slight increase and 5 cases (17.2%) decrease in value. Judged from the aggravation degree of clinical features, long‐termed deteriorated group manifested a tendency to slight decrease in comparison with the other group, and the group with abnormal PEG findings showed evidently lower value than the normal group. 3 In the PBP‐ratio (%) for total CSF proterin, the normal control group a distribution ranging from 2.5 to 4.0%. This value regarded as standard and over 4.1% as increase and below 2.4% as decrease, a great many schizophrenic cases gave a tendency toward decrease, especially conspicuous in long‐termed deteriorated patients with abnormal PEG findings. 4 From the above, it may be suggested that the variation of liquor‐PBP has not always correlation with that of total protein, and that the degenerative‐atrophic mechanisms of the brain plays a role as the factor working decreasing upon the CSF‐PBP values.