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LSD‐25, MESCALINE INDUCED PSYCHOSIS AND CATECHOL AMINE METABOLISM
Author(s) -
Sakamoto Kenji
Publication year - 1959
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1959.tb02437.x
Subject(s) - adrenochrome , mescaline , neuromelanin , psychosis , lysergic acid diethylamide , hallucinogen , abnormality , chemistry , pharmacology , psychology , in vivo , anesthesia , neuroscience , medicine , psychiatry , dopamine , epinephrine , dopaminergic , biology , receptor , substantia nigra , serotonin , microbiology and biotechnology
In 1954, Hoffer et al. 1) prepared adrenochrome and administrated it to themselves and to other volunteers. They found that it produces the most powerful pseudo‐schizophrenic sydromes yet described, far more closely resembling an actual psychosis than any of other hallucinogenes. In an individual under the influence of adrenohrome, the insight into his own mental changes is completely lost. In addition Szatmai, Hoffer and Schneider 2) reported that intravenous administration of adrenochrome increased the E.E.G. abnormality of deteriorated epileptic patients. More recently, they added to the above fact that adrenolutine had same kind of effect. 3) The agents are considered to be “in vivo” substances and adrenaline derivatives. Thereupon, Hoffer 1) offered a hypothesis asserting that, in the schizophrenic patients under stress, the quantity of adrenaline in the body is increased, while these might be turned into adrenochrome or some similar substances.