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EFFECTS OF WAKE AMINE UPON THE METABOLISM OF GLUTAMIC ACID IN THE BRAIN
Author(s) -
Maeda Akio
Publication year - 1958
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1958.tb02885.x
Subject(s) - glutamic acid , glutamine , in vivo , transamination , chemistry , pharmacology , drug , in vitro , amine gas treating , human brain , biochemistry , metabolism , amino acid , biology , neuroscience , organic chemistry , microbiology and biotechnology
Summary Effects of wake amine, β‐phenyrl‐isopropyl‐amine, on the metabolism of glutamic acid in the brain were observed in vitro and a long term basis in vivo. The results obtained were as follows: 1. In the brain homogenate without my substrate, this drug showed depressive effects on the reduction of TTC. 2. When glutamic acid was added as substrate to the brain, the reduction of TTC was not influenced by this drug. 3. When glutamine was added to the brain as substrate, the reduction of TTC was depressed by this drug. 4. This drug works depressing on activity of glutaminse in the brain. 5. There was no effect of this drug on the vegetative and cerebral decaroxylase of glutamic acid. 6. In vitro, no effect was detected on the transamination between α‐ketoglutaric acid nor γ‐aminobutyric acid nor α‐alanine in the brain but, in a long term administration, depressive effects of this drug on these two transaminations were obtained. 7. This drug, when used in vitro and vivo, showed accelerating effects toward an increase of NH 3 in thc brain after decapitation.