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HISTAMINE EFFECT UPON THE SYMPTOMS OF LSD 25 * INTOXICATION
Author(s) -
Yamada Toshiji,
Takumi Akira
Publication year - 1956
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1956.tb01088.x
Subject(s) - histamine , histamine antagonists , lysergic acid diethylamide , inhibitory postsynaptic potential , realm , histamine h1 antagonists , pharmacology , chemistry , medicine , receptor , political science , serotonin , law
Summary Histamine was injected intravenously to nine subjects developing the florid LSD symptoms. It was found that in seven of nine cases the symptoms went inhibited markedly by merit of histamine. The changes in the LSD symptoms under that circumstance were described concretely. On the basis of the results obtained, standard of dose and epoch of histamine usage necessary for obtaining the expected effect was discussed. The inhibitory effect of histamine upon LSD reaction fell very much similar to that of the succinate and the nicotinic acid. In conclusion it is supposed that three drugs shall display their action ultimately in the realm of functional metabolism of the nervous tissues through a common effecting course.