STUDIES ON EXPERIMENTAL ALLERGIC ENCEPHALITIS Report 1. Observation on Allergic Encephalitis Experimentally Produced by the Use of White Matter Phosphatide conjugated with Bovine Serum.

Summary 1) 5 rabbits were divided into 2 goups; namely, 3 as the main experiment group and 2 as the control group. To the former group the cerebral white matter phosphatide conjugated with bovine serum was injected into the auricular vein 20–34 times during a period of 91–165 days; and to the control group the white matter phosphatide alone was injected in the same way. 2) Clinically, the main experiment group showed eventually transient paralysis, cramp, ptosis, loss of the pupillar reaction to light, nystagmus, pendulum‐like oscillation of the head, irritability, etc. interpretable as symptoms from the side of central nervous system. 3) Histologically, the main experiment group had the larger number of the nerve cell changes consisting of peiinuclear chromatolysis nearly all over the cortical areas compared with the control group. The said perinuclear change covered nearly all the layers, but appeared particularly marked in the layers III, IV and VI. In the nuclei of the brain stem a large number of the cells with similar perinuclear rhromatolysis were found in the nuclei basales and both upper and lower corpora quadrigemina. Although the vascular walls were found hypertrophic, no clotting nor hemorrhage was detectable. Slight cell infiltration and demyelination made out the changes exclusively discernible in the white matter. Also, some inflammatory cell infiltration was detected in the sciatic nerves of the main experiment group.