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Morhologic Study of the Experimental Brain Tumor. (1st Report: Intracerebral Inoculation of Suspeneion of Yoshida Sarcoma)
Author(s) -
Yoshida Nobuo,
Ōyama Hiroshi,
Kurobane Takeski
Publication year - 1948
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1948.tb01144.x
Subject(s) - infiltration (hvac) , sarcoma , pathology , gliosarcoma , glioma , autopsy , biology , immunohistochemistry , cancer research , medicine , physics , thermodynamics
Résumé.1) An intracerebral inoculation of Yoshida sarconia brought a positive result in the albino rats, 38 in all. 2) Autopsy return revealed abscess‐like infiltration of the brain, associated with extensive invasion in the subarachnoidal space by the tumor cells. 3) The tumor cells exhibited various modes of proliferation in adjustment to the local tissue structure. Thereby analogous findings in certain forms of gliomata were discussed. 4) Mixture of sarcoma cells and astrocytes often prepared so compound a picture resembling gliosarcoma, that it was found beyond the capacity of any specific gliastaining method to distinguish between glioma and sarcoma. 5) At earlier stages of infiltration, emigration of the tumor cells into the spongioplasma suggests the existence of a non‐visible current penetrating the brain substance. 6) Yoshida sarcoma does not need in the way of development either specific intercellular substance or active proliferation of the blood vessels. It possesses a strong ability of tissue dissolution and executes peptisation of the glial and neuronal tissues.