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Relationships between tumour necrosis factor‐α, interleukin‐12B and interleukin‐10 gene polymorphisms and hepatitis B in Chinese Han haemodialysis patients
Author(s) -
WANG CUIYU,
ZHANG XIAOLI,
ZHU BEI,
HU DALAN,
WU JIANQING,
YU RONGBIN,
ZHAO WEIHONG
Publication year - 2012
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2011.01539.x
Subject(s) - genotype , genotyping , medicine , restriction fragment length polymorphism , untranslated region , hepatitis b virus , interleukin , allele , gene , immunology , virology , cytokine , biology , virus , genetics , messenger rna
ABSTRACT: Aim: To investigate the possible association of gene polymorphisms of tumour necrosis factor (TNF)‐α (‐238 and ‐308), interleukin (IL)‐10 (‐592 and ‐819) and 3′ untranslated region (3′UTR) of the IL12B (‐1188) and hepatitis B in Chinese Han haemodialysis (HD) patients. Methods: The genotyping of TNF‐α ‐238 and ‐308, IL‐10 ‐592 and ‐819 and 3′UTR of the IL12B were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Results: The TNF ‐α‐238 A allele, the IL12B 3′UTR C/C, C/A genotypes were associated with decreased susceptibility to hepatitis B viral infection ( P = 0.047, P = 0.003 and P = 0.001 respectively). The frequencies of IL‐10–592 A/A genotype, IL‐10–819 T/T genotype were lower in the HBV persistence group ( P = 0.029 and P = 0.019) than those in the virus clearance group. Conclusions: TNF‐α and IL12B 3′UTR gene polymorphisms may be associated with HBV susceptibility and IL‐10 gene polymorphisms may be related to the HBV persistence infection in Chinese Han HD patients.