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Association between interleukin‐10 gene polymorphism −592 (A/C) and peritoneal transport in patients undergoing peritoneal dialysis
Author(s) -
LEE YUEHTING,
TSAI YUCHE,
YANG YUKUN,
HSU KUOTAI,
LIAO SHANGCHIH,
WU CHIENHSING,
CHENG BENCHUNG,
CHEN JINBOR,
LEE CHIHHSIUNG,
LEE CHIENTE
Publication year - 2011
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2011.01496.x
Subject(s) - medicine , peritoneal equilibration test , peritoneal dialysis , odds ratio , genotype , gastroenterology , creatinine , single nucleotide polymorphism , allele , continuous ambulatory peritoneal dialysis , gene , genetics , biology
Aim: The aim of this analysis was to know whether these three cytokine polymorphisms, including interleukin‐6 (IL‐6; −572 G/C), tumour necrosis factor‐α (TNF‐α; −308 G/A), and IL‐10 (–592 A/C) have an effect on baseline peritoneal transport property and longitudinal evolution of peritoneal function. Methods: A total of 141 stable peritoneal dialysis (PD) patients with mean treatment duration of 84.4 ± 34.2 months were enrolled. We genotyped these three cytokine polymorphisms, together with clinical parameters that were included as factors affecting longitudinal change of property of peritoneal transport over the first 3 year period after commencing therapy. Results: There was no significant association between genotypes and baseline peritoneal transport property. The −592 A/C polymorphism of IL‐10 was associated with longitudinal change of peritoneal transport. The ratio of D/P creatinine was significantly higher in patients with AA than those with CC/CA genotypes at 12 months (0.65 ± 0.11 vs 0.62 ± 0.09, P = 0.048) and 24 months (0.64 ± 0.12 vs 0.59 ± 0.09, P = 0.018). In addition, patients with increased peritoneal transport have greater frequency distribution of AA genotype and A allele. Logistic regression analysis revealed that −592 A allele was an independent predictor for the increase in D/P creatinine over the first 12 month period (odds ratio: 2.482, P = 0.017). There was no correlation between either polymorphism of IL‐6 −572 (G/C) or TNF‐α−308 (G/A) and longitudinal change of peritoneal function. Conclusions: Single nucleotide polymorphism of IL‐10 −592 (A/C) was associated with longitudinal evolution of peritoneal transport rate in PD patients rather than the baseline peritoneal characteristics.