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Urinary transforming growth factor‐β1 in children with obstructive uropathy
Author(s) -
ZIEG JAKUB,
BLAHOVA KVETA,
SEEMAN TOMAS,
BRONSKY JIRI,
DVORAKOVA HANA,
PECHOVA MARTA,
JANDA JAN,
MATOUSOVIC KAREL
Publication year - 2011
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2011.01459.x
Subject(s) - medicine , obstructive uropathy , urinary system , creatinine , proteinuria , urology , hydronephrosis , renal function , transforming growth factor , beta 2 microglobulin , microalbuminuria , posterior urethral valve , endocrinology , gastroenterology , kidney
Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor‐β1 (TGF‐β1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF‐β1 levels in children with obstructive and non‐obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non‐obstructive hydronephrosis and 21 healthy children. Urinary TGF‐β1, proteinuria, microalbuminuria and urinary α1‐microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF‐β1 concentrations in patients with OU were significantly higher than those with NOU (4.14 ± 0.67 creatinine vs 1.80 ± 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 ± 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF‐β1 concentrations with proteinuria ( r = 0.87, P < 0.0001) and urinary α1‐microglobulin ( r = 0.82, P = 0.0002) were found in patients with OU. Conclusion: Children with OU have higher urinary TGF‐β1 than children with NOU. Urinary TGF‐β1 may be a useful non‐invasive tool for the differential diagnosis between OU and NOU in children. A positive correlation of TGF‐β1 with markers of renal tissue damage in patients with OU was found.