Premium
Tissue level of advanced glycation end products is an independent determinant of high‐sensitivity C‐reactive protein levels in haemodialysis patients
Author(s) -
NAGANO MAKIO,
FUKAMI KEI,
YAMAGISHI SHOICHI,
SAKAI KAZUKO,
KAIDA YUSUKE,
MATSUMOTO TAKAFUMI,
HAZAMA TAKUMA,
TANAKA MASAHIRO,
UEDA SEIJI,
OKUDA SEIYA
Publication year - 2011
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2010.01419.x
Subject(s) - medicine , glycation , sensitivity (control systems) , c reactive protein , advanced glycation end product , biochemistry , receptor , inflammation , chemistry , electronic engineering , engineering
Aim: C‐reactive protein (CRP) level predicts future cardiovascular events in patients on haemodialysis (HD). Advanced glycation end products (AGE) play a role in cardiovascular disease (CVD) in HD patients. However, which variables including tissue AGE levels are independently associated with CRP remains unknown. Therefore, whether tissue AGE and CRP levels were correlated with atherosclerosis in HD patients was examined. Methods: Fifty‐four HD patients underwent determinations of blood chemistries and tissue AGE. Tissue AGE levels were evaluated by measuring skin autofluorescence. Pulsatility index (PI) in the carotid artery was measured using a Doppler ultrasonography. Results: Univariate analyses showed that age, white blood cells, serum albumin (inversely), alkaline phosphatase (inversely), tartrate‐resistant acid phosphatase 5b (TRAP5b) (inversely) and skin AGE levels were significantly correlated with high‐sensitivity CRP (hsCRP). Multiple stepwise regression analysis revealed that serum albumin, TRAP5b and skin AGE levels were independent determinants of hsCRP. Further, PI was highest among HD patients with high skin AGE and high hsCRP levels. Conclusion: The present study suggests that tissue AGE level is one of the independent determinants of hsCRP in HD patients. Tissue AGE and hsCRP levels may be correlated with each other, which could in concert contribute to the progression of atherosclerosis in these subjects.