Premium
Association of polymorphisms within the transforming growth factor‐β1 gene with diabetic nephropathy and serum cholesterol and triglyceride concentrations
Author(s) -
VALLADARESSALGADO ADÁN,
ANGELESMARTÍNEZ JAVIER,
ROSAS MARISOL,
GARCÍAMENA JAIME,
UTRERABARILLAS DOLORES,
GÓMEZDÍAZ RITA,
ESCOBEDODE LA PEÑA JORGE,
PARRA ESTEBAN J,
CRUZ MIGUEL
Publication year - 2010
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2010.01302.x
Subject(s) - medicine , odds ratio , diabetic nephropathy , endocrinology , genotype , triglyceride , diabetes mellitus , nephropathy , confidence interval , cholesterol , type 2 diabetes mellitus , kidney disease , polymorphism (computer science) , gastroenterology , gene , biology , genetics
Aim: The TGF‐β gene participates in the development of chronic kidney disease. We investigated whether the 869 T > C, 915 G > C and −800 G > A polymorphisms of TGF‐β1 are associated with diabetic nephropathy (DN). Methods: Polymorphisms were genotyped in 439 type 2 diabetes mellitus patients, 233 with diabetic nephropathy (DN+) and 206 without (DN–). The sample was characterized for relevant clinical and biochemical parameters. Results: The 869 T > C ( P = 0.016; odds ratio (OR) = 1.818, 95% confidence interval (CI) = 1.128–2.930) and the 915 G > C polymorphisms ( P = 0.008, OR = 4.073, 95% CI = 1.355–12.249) were associated with diabetic nephropathy. The 869 T > C variant was associated with total cholesterol levels: CC + CT genotypes had a mean cholesterol concentration of 5.62 ± 1.40 mmol/L vs a mean concentration of 5.15 ± 1.40 mmol/L for the TT genotype ( P = 0.011). Triglycerides were also higher in CC + CT genotypes (2.49 ± 1.56 mmol/L) in comparison with TT homozygotes (2.1 ± 1.22 mmol/L, P = 0.042). Multivariate logistic regression showed that the polymorphisms 869 T > C and 915 G > C were independent predictors for DN ( P = 0.049 and 0.046, respectively). Conclusion: The 869 T > C and 915 G > C polymorphisms within the TGF‐β1 gene were associated with DN+. Lower cholesterol and triglycerides levels were observed in TT homozygotes for the 869 T > C polymorphism. The TGF‐β1 869 T allele seems to confer protection against DN+.