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Change of glomerular filtration rate in healthy adults with aging
Author(s) -
SUN XUEFENG,
CHEN YUNSHUANG,
CHEN XIANGMEI,
WANG JIANZHONG,
XI CHUNSHENG,
LIN SHUPENG,
LIU XIUJUAN
Publication year - 2009
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2009.01098.x
Subject(s) - renal function , cystatin c , medicine , creatinine , urology , endocrinology , body surface area , plasma clearance , receiver operating characteristic , pharmacokinetics
SUMMARY Aim: In order to determine the relationship between glomerular filtration rate (GFR) and age, the associated factors, and the accurate method of GFR in healthy adults, we conducted a cross‐sectional study in community‐dwelling adults in Beijing. Methods: Renal function of 201 clinically healthy subjects was determined using technetium‐99 m‐labelled diethylene triamine pentacetic acid ( 99m Tc‐DTPA). Estimated GFR was calculated with the Cockcroft–Gault (CG) equation, abbreviated Modification of Diet in Renal Disease (MDRD) equation, and plasma clearance of creatinine (Ccr). Serum cystatin C, biomarkers of inflammatory and endothelial cells were analyzed as well. Protein intake, carotid artery intima‐media thickness and plaque formation were assayed as well. Results: Glomerular filtration rate was negatively associated with age and the correlation coefficient for 99m Tc‐GFR, CG‐GFR, MDRD‐GFR, Ccr were −0.643, −0.736, −0.55 and −0.619, respectively ( P < 0.001), while the correlation coefficient between cystatin C and age was 0.681 ( P < 0.001). Estimated GFR were associated with measured GFR, and the correlation coefficient for Ccr, CG‐GFR and MDRD‐GFR were 0.813, 0.582 and 0.418, respectively ( P < 0.001). The area under the receiver–operator curve of Ccr was larger, CG was smaller while MDRD was the smallest, and the difference was significant ( P < 0.001). So a predicted equation was presented by cystatin C and C‐reactive protein for the elderly. Conclusion: In the clinically healthy adults, GFR declined with age. MDRD and CG equation are not suitable to estimate GFR in healthy adults. The predicted equation established by cystatin C and C‐reactive protein may be more accurate.